30 lines
2.1 KiB
BibTeX
30 lines
2.1 KiB
BibTeX
@article{levental2009,
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abstract = {Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis is accompanied by collagen crosslinking, ECM stiffening, and increased focal adhesions. Induction of collagen crosslinking stiffened the ECM, promoted focal adhesions, enhanced PI3 kinase (PI3K) activity, and induced the invasion of an oncogene-initiated epithelium. Inhibition of integrin signaling repressed the invasion of a premalignant epithelium into a stiffened, crosslinked ECM and forced integrin clustering promoted focal adhesions, enhanced PI3K signaling, and induced the invasion of a premalignant epithelium. Consistently, reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence. These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy. © 2009 Elsevier Inc. All rights reserved.},
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author = {Kandice R. Levental and Hongmei Yu and Laura Kass and Johnathon N. Lakins and Mikala Egeblad and Janine T. Erler and Sheri F.T. Fong and Katalin Csiszar and Amato Giaccia and Wolfgang Weninger and Mitsuo Yamauchi and David L. Gasser and Valerie M. Weaver},
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doi = {10.1016/J.CELL.2009.10.027},
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issn = {0092-8674},
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issue = {5},
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journal = {Cell},
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keywords = {CELLBIO,HUMDISEASE},
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month = {11},
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pages = {891-906},
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pmid = {19931152},
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publisher = {Cell Press},
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title = {Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling},
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volume = {139},
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year = {2009},
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}
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@generic{frantz2010,
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author = {Christian Frantz and Kathleen M. Stewart and Valerie M. Weaver},
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doi = {10.1242/jcs.023820},
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issn = {00219533},
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issue = {24},
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journal = {Journal of Cell Science},
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month = {12},
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pages = {4195-4200},
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pmid = {21123617},
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title = {The extracellular matrix at a glance},
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volume = {123},
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year = {2010},
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}
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